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Gene Review

Prl2c3  -  prolactin family 2, subfamily c, member 3

Mus musculus

Synonyms: MRP-2, MRP-3, Mitogen-regulated protein 2, Mitogen-regulated protein 3, Mrp2, ...
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Disease relevance of Prl2c3

  • An MRP-2 monoclonal antibody (MoAb) was primarily a product of hybridoma selected by binding to poly(ADP-ribose) from a lupus prone MRL/Mp-lpr/lpr (MRL/l) mouse, and was shown to cross-react with single-stranded (ss) DNA [1].

High impact information on Prl2c3

  • Rodents deficient in three known ABC family transporters (MRP1, MRP2, and MDR1a/1b) exhibited urinary arsenic levels similar or greater than those in wild-type rodents; however, administration of MK571, an MRP inhibitor, reduced urinary arsenic excretion by almost 50% [2].
  • A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells [3].
  • The growth of various hematopoietic and stromal cell lines treated with PLF2 was found to increase by 4-27%, as measured by cell count and DNA synthesis assay [3].
  • Proliferin-2 (PLF2) increased the frequency of long-term culture-initiating cells (LTC-IC) from 1 in 340 to 1 in 256 of the primary hematopoietic stem cell (HSC)-enriched bone marrow cells grown on MS5.1 feeder layer [3].
  • Mrp2 cDNAs were isolated from BALB/c and Macaca fascicularis liver, respectively, and vesicle transport studies were performed using recombinant Mrp2s expressed in insect Sf9 cells [4].

Anatomical context of Prl2c3

  • MRP-2 MoAb was found to induce hematoxylin bodies, LE rosettes and LE cells, but a direct LE test using MRL/n mouse blood did not induce LE cell phenomena [1].


  1. Lupus erythematosus cell formation by a monoclonal antibody derived from an autoimmune MRL/Mp-lpr/lpr mouse. Kanai, Y., Yamauchi, S., Hashiba-Kanai, Y. Immunol. Lett. (1989) [Pubmed]
  2. Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione. Kala, S.V., Kala, G., Prater, C.I., Sartorelli, A.C., Lieberman, M.W. Chem. Res. Toxicol. (2004) [Pubmed]
  3. A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells. Choong, M.L., Tan, A.C., Luo, B., Lodish, H.F. FEBS Lett. (2003) [Pubmed]
  4. Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (mrp2). Ninomiya, M., Ito, K., Hiramatsu, R., Horie, T. Drug Metab. Dispos. (2006) [Pubmed]
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