The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Prl2c3  -  prolactin family 2, subfamily c, member 3

Mus musculus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Prl2c3

  • An MRP-2 monoclonal antibody (MoAb) was primarily a product of hybridoma selected by binding to poly(ADP-ribose) from a lupus prone MRL/Mp-lpr/lpr (MRL/l) mouse, and was shown to cross-react with single-stranded (ss) DNA [1].
 

High impact information on Prl2c3

  • Rodents deficient in three known ABC family transporters (MRP1, MRP2, and MDR1a/1b) exhibited urinary arsenic levels similar or greater than those in wild-type rodents; however, administration of MK571, an MRP inhibitor, reduced urinary arsenic excretion by almost 50% [2].
  • A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells [3].
  • The growth of various hematopoietic and stromal cell lines treated with PLF2 was found to increase by 4-27%, as measured by cell count and DNA synthesis assay [3].
  • Proliferin-2 (PLF2) increased the frequency of long-term culture-initiating cells (LTC-IC) from 1 in 340 to 1 in 256 of the primary hematopoietic stem cell (HSC)-enriched bone marrow cells grown on MS5.1 feeder layer [3].
  • Mrp2 cDNAs were isolated from BALB/c and Macaca fascicularis liver, respectively, and vesicle transport studies were performed using recombinant Mrp2s expressed in insect Sf9 cells [4].
 

Anatomical context of Prl2c3

  • MRP-2 MoAb was found to induce hematoxylin bodies, LE rosettes and LE cells, but a direct LE test using MRL/n mouse blood did not induce LE cell phenomena [1].

References

  1. Lupus erythematosus cell formation by a monoclonal antibody derived from an autoimmune MRL/Mp-lpr/lpr mouse. Kanai, Y., Yamauchi, S., Hashiba-Kanai, Y. Immunol. Lett. (1989) [Pubmed]
  2. Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione. Kala, S.V., Kala, G., Prater, C.I., Sartorelli, A.C., Lieberman, M.W. Chem. Res. Toxicol. (2004) [Pubmed]
  3. A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells. Choong, M.L., Tan, A.C., Luo, B., Lodish, H.F. FEBS Lett. (2003) [Pubmed]
  4. Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (mrp2). Ninomiya, M., Ito, K., Hiramatsu, R., Horie, T. Drug Metab. Dispos. (2006) [Pubmed]
 
WikiGenes - Universities