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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Prkcsh  -  protein kinase C substrate 80K-H

Mus musculus

Synonyms: 80K-H, 80K-H protein, Glucosidase 2 subunit beta, Glucosidase II subunit beta, PKCSH, ...
 
 
 
 
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High impact information on Prkcsh

  • Electrophysiological studies using 80K-H mutants showed that three domains of 80K-H (the two EF-hand structures, the highly acidic glutamic stretch, and the His-Asp-Glu-Leu sequence) are critical determinants for TRPV5 activity [1].
  • 80K-H was initially identified as a protein kinase C substrate, but its biological function remains to be established [1].
  • None of the 80K-H mutants altered the TRPV5 plasma membrane localization nor the association of 80K-H with TRPV5, suggesting that 80K-H has a direct effect on TRPV5 activity [1].
 

Biological context of Prkcsh

  • Furthermore, 80K-H directly bound Ca(2+), and inactivation of its two EF-hand structures totally abolished Ca(2+) binding [1].
 

Analytical, diagnostic and therapeutic context of Prkcsh

  • By the use of cDNA microarrays, the present study identified 80K-H as the first protein involved in the Ca(2+)-dependent control of the epithelial Ca(2+) channel TRPV5 [1].

References

  1. 80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5). Gkika, D., Mahieu, F., Nilius, B., Hoenderop, J.G., Bindels, R.J. J. Biol. Chem. (2004) [Pubmed]
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