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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rufy1  -  RUN and FYVE domain containing 1

Mus musculus

Synonyms: 3000002E04Rik, RUN and FYVE domain-containing protein 1, Rab4-interacting protein, Rabip4, ZFYVE12
 
 
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High impact information on Rufy1

  • Furthermore, the expression of Rabip4 leads to the intracellular retention of a recycling molecule, the glucose transporter Glut 1 [1].
  • The coexpression of Rabip4 with active Rab4, but not with inactive Rab4, leads to an enlargement of early endosomes [1].
  • We present evidence that Rabip4 defines a subdomain of early endosomes and that Rabip4 is redistributed to the plasma membrane by insulin [2].
 

Anatomical context of Rufy1

  • We propose that Rabip4, an effector of Rab4, controls early endosomal traffic possibly by activating a backward transport step from recycling to sorting endosomes [1].

References

  1. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Cormont, M., Mari, M., Galmiche, A., Hofman, P., Le Marchand-Brustel, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes. Mari, M., Monzo, P., Kaddai, V., Keslair, F., Gonzalez, T., Le Marchand-Brustel, Y., Cormont, M. J. Cell. Sci. (2006) [Pubmed]
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