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Gene Review

NID2  -  nidogen 2 (osteonidogen)

Homo sapiens

Synonyms: NID-2, Nidogen-2, Osteonidogen
 
 
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Disease relevance of NID2

 

High impact information on NID2

  • The entactin/nidogen (E/N) family has expanded with the recent description of a new isoform, E/N-2/osteonidogen [2].
  • Furthermore, demethylation of the NID1 and NID2 promoters restored gene transcription, demonstrating that methylation was responsible for silencing nidogen genes [1].
  • Thoracic discharges from NID-1 were more likely to stimulate the myocardium than those from NID-2 (98% vs. 54%, p = 0.0007) [3].
 

Biological context of NID2

 

Anatomical context of NID2

  • Two different commercially available models (NID-1 and NID-2), two different vectors of discharges (thoracic: parallel to the long axis of the heart on the chest wall, and nonthoracic: away from the chest, across the abdomen), and two different durations of discharge (5 and 15 s) were tested [3].

References

  1. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. Ulazzi, L., Sabbioni, S., Miotto, E., Veronese, A., Angusti, A., Gafà, R., Manfredini, S., Farinati, F., Sasaki, T., Lanza, G., Negrini, M. Mol. Cancer (2007) [Pubmed]
  2. Still more complexity in mammalian basement membranes. Erickson, A.C., Couchman, J.R. J. Histochem. Cytochem. (2000) [Pubmed]
  3. Cardiac electrophysiological consequences of neuromuscular incapacitating device discharges. Nanthakumar, K., Billingsley, I.M., Masse, S., Dorian, P., Cameron, D., Chauhan, V.S., Downar, E., Sevaptsidis, E. J. Am. Coll. Cardiol. (2006) [Pubmed]
 
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