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Gene Review:

ABCB10 - ATP-binding cassette, sub-family B...

Homo sapiens

Synonyms: ABC transporter 10 protein, ATP-binding cassette sub-family B member 10, mitochondrial, ATP-binding cassette transporter 10, EST20237, M-ABC2, ...

Graf, S.A. et al., Herget, M. et al., Allikmets, R. et al.

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High impact information on ABCB10

The N-terminal subdomain (aa 1-35) of the mTP, although not necessary for the trafficking of ABCB10 to mitochondria, participates in the proper import of the molecule into the inner membrane [1].
A deletion mutant of ABCB10 that lacks its mTP efficiently targets to the endoplasmic reticulum [1].
Two new ABC genes (EST20237, 31252) are located at Chromosome (Chr) 1q42 and 1q25 respectively in humans, as determined by FISH; at locations distinct from previously mapped genes of this superfamily [2].
ABCB8 and ABCB10 are targeted to the inner mitochondrial membrane [3].
As such peptides are presented as minor histocompatibility antigens on the surface of mammalian cells, a physiological role of ABCB10 in the antigen processing can be accounted [3].

References

Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). Graf, S.A., Haigh, S.E., Corson, E.D., Shirihai, O.S. J. Biol. Chem. (2004) [Pubmed]
Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database. Allikmets, R., Gerrard, B., Glavac, D., Ravnik-Glavac, M., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Modi, W., Dean, M. Mamm. Genome (1995) [Pubmed]
Intracellular peptide transporters in human - compartmentalization of the "peptidome". Herget, M., Tampé, R. Pflugers Arch. (2007) [Pubmed]

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AgaP_AGAP002717	Anopheles gambiae str. PEST
TAP2	Arabidopsis thaliana
AGOS_ACR022W	Ashbya gossypii ATCC 10895
ABCB10	Bos taurus
haf-1	Caenorhabditis elegans
haf-3	Caenorhabditis elegans
ABCB10	Canis lupus familiaris
abcb10	Danio rerio
CG3156	Drosophila melanogaster
ABCB10	Gallus gallus
KLLA0D00748g	Kluyveromyces lactis NRRL Y-1140
ABCB10	Macaca mulatta
MGG_06878	Magnaporthe oryzae 70-15
Abcb10	Mus musculus
NCU04117	Neurospora crassa OR74A
Os03g0755100	Oryza sativa Japonica Group
LOC469706	Pan troglodytes
Abcb10	Rattus norvegicus
MDL2	Saccharomyces cerevisiae S288c
mdl1	Schizosaccharomyces pombe 972h-

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