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Gene Review

ALS3  -  amyotrophic lateral sclerosis 3 (autosomal...

Homo sapiens

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Disease relevance of ALS3


High impact information on ALS3

  • However, familial forms of ALS have been described--autosomal dominant forms (ALS1, ALS3), clinically indistinguishable from the sporadic form, and autosomal recessive forms with early onset and slower progression of symptoms (ALS2) [2].
  • GFP production from the ALS1 and ALS3 promoters was detected immunohistochemically [3].
  • Candida albicans ALS3 encodes a large cell-surface glycoprotein that has adhesive properties [4].
  • Despite its inability to restore wild-type biofilm mass, the Als3p-Ag alpha 1p fusion protein mediated adhesion of the als3 Delta/als3 Delta C. albicans strain to human buccal epithelial cells (BECs) [4].
  • Clades differed with respect to prevalent ALS3 alleles and allele distribution, but were similar for the mean number of tandem repeat copies per ALS3 allele [5].

Biological context of ALS3

  • Candida albicans strain SC5314 contains two ALS3 alleles, which differ in sequence with respect to the number of copies of the 108 bp tandem repeat sequence within the central domain of the coding region [5].

Anatomical context of ALS3

  • Wild-type C. albicans (ALS3(12)/ALS3(9)) and those containing various ALS3 alleles (ALS3(12)/als3Delta(9), als3Delta(12)/ALS3(9) and als3Delta(12)/als3Delta(9)) were assayed for adhesion to monolayers of cultured vascular endothelial and pharyngeal epithelial cells [5].


  1. Excitability changes during the recovery cycle of human myelinated motor and sensory axons in normal case and in amyotrophic lateral sclerosis. Stephanova, D.I., Daskalova, M., Kristev, I. Acta physiologica et pharmacologica Bulgarica. (2001) [Pubmed]
  2. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Hentati, A., Bejaoui, K., Pericak-Vance, M.A., Hentati, F., Speer, M.C., Hung, W.Y., Figlewicz, D.A., Haines, J., Rimmler, J., Ben Hamida, C. Nat. Genet. (1994) [Pubmed]
  3. Use of green fluorescent protein and reverse transcription-PCR to monitor Candida albicans agglutinin-like sequence gene expression in a murine model of disseminated candidiasis. Green, C.B., Zhao, X., Hoyer, L.L. Infect. Immun. (2005) [Pubmed]
  4. Candida albicans Als3p is required for wild-type biofilm formation on silicone elastomer surfaces. Zhao, X., Daniels, K.J., Oh, S.H., Green, C.B., Yeater, K.M., Soll, D.R., Hoyer, L.L. Microbiology (Reading, Engl.) (2006) [Pubmed]
  5. Functional specificity of Candida albicans Als3p proteins and clade specificity of ALS3 alleles discriminated by the number of copies of the tandem repeat sequence in the central domain. Oh, S.H., Cheng, G., Nuessen, J.A., Jajko, R., Yeater, K.M., Zhao, X., Pujol, C., Soll, D.R., Hoyer, L.L. Microbiology (Reading, Engl.) (2005) [Pubmed]
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