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Gene Review

TAS2R31  -  taste receptor, type 2, member 31

Homo sapiens

Synonyms: T2R31, T2R44, T2R53, TAS2R44, Taste receptor type 2 member 31, ...
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High impact information on TAS2R44

  • Here we report identification of two novel ligand-receptor pairs. hT2R61 is activated by 6-nitrosaccharin, a bitter derivative of saccharin. hT2R44 is activated by denatonium and 6-nitrosaccharin [1].
  • Thus, hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K [2].

Associations of TAS2R44 with chemical compounds

  • Here, we show by functional expression experiments in human embryonic kidney cells that saccharin and acesulfame K activate two members of the human TAS2R family (hTAS2R43 and hTAS2R44) at concentrations known to stimulate bitter taste [2].


  1. Identification of ligands for two human bitter T2R receptors. Pronin, A.N., Tang, H., Connor, J., Keung, W. Chem. Senses (2004) [Pubmed]
  2. Bitter taste receptors for saccharin and acesulfame K. Kuhn, C., Bufe, B., Winnig, M., Hofmann, T., Frank, O., Behrens, M., Lewtschenko, T., Slack, J.P., Ward, C.D., Meyerhof, W. J. Neurosci. (2004) [Pubmed]
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