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Gene Review

MTBP  -  MDM2 binding protein

Homo sapiens

Synonyms: Mdm2-binding protein, hMTBP
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Disease relevance of MTBP

  • This study demonstrates that the human choriocarcinoma cell line (JEG-3) also contains the MTBP and that in both human placenta and JEG-3 cells the MTBP is located exclusively in the nucleus and in particular is associated with DNase 1 resistant chromatin [1].

High impact information on MTBP


Biological context of MTBP


Associations of MTBP with chemical compounds


Physical interactions of MTBP

  • Using a yeast two-hybrid screen, we have identified a gene that encodes a novel cellular protein (MTBP) that binds to MDM2 [3].

Other interactions of MTBP

  • MTBP can induce G(1) arrest, which in turn can be blocked by MDM2 [3].


  1. The methyltrienolone binding protein of JEG-3 cells and human placenta is localized within the nucleus and is tightly associated with chromatin. Macaulay, J.O., Warne, G.L., Krozowski, Z.S. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  2. Regulation of p53 and MDM2 activity by MTBP. Brady, M., Vlatkovic, N., Boyd, M.T. Mol. Cell. Biol. (2005) [Pubmed]
  3. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. Boyd, M.T., Vlatkovic, N., Haines, D.S. J. Biol. Chem. (2000) [Pubmed]
  4. Structure-specific DNA-binding proteins as the foundation for three-dimensional chromatin organization. Podgornaya, O.I., Voronin, A.P., Enukashvily, N.I., Matveev, I.V., Lobov, I.B. Int. Rev. Cytol. (2003) [Pubmed]
  5. The methyltrienolone binding protein of human placenta requires nicotinamide adenine dinucleotide cofactor(s) for steroid binding. Macaulay, J.O., Warne, G.L., Smith, A.I., Krozowski, Z.S. Endocrinology (1990) [Pubmed]
  6. Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization. Boyd, M.T., Zimonjic, D.B., Popescu, N.C., Athwal, R., Haines, D.S. Cytogenet. Cell Genet. (2000) [Pubmed]
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