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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Atp1a4  -  ATPase, Na+/K+ transporting, alpha 4...

Mus musculus

Synonyms: Atp1al2, Na(+)/K(+) ATPase alpha-4 subunit, Sodium pump subunit alpha-4, Sodium/potassium-transporting ATPase subunit alpha-4
 
 
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High impact information on Atp1a4

  • The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1 [1].
  • By hybridizing an alpha4 probe with a series of BACs, we localized the alpha4 subunit gene (Atp1a4) to the distal portion of mouse chromosome 1, in very close proximity to the murine Na,K-ATPase alpha2 subunit gene [1].
  • Predictive analysis of promoter regions identified muscle specific regulatory elements for ATP1A4 and Atp1a4 [2].
  • Human ATP1A4 gene shares 84% identity with the mouse Atp1a4 gene, and both consist of 22 exons and 21 introns [2].

References

  1. The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Underhill, D.A., Canfield, V.A., Dahl, J.P., Gros, P., Levenson, R. Biochemistry (1999) [Pubmed]
  2. Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. Keryanov, S., Gardner, K.L. Gene (2002) [Pubmed]
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