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Gene Review:

GNB1 - guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transducin beta chain 1

Kitanaka, J. et al.

Kitanaka, Kitanaka, Takemura, Wang, Hembree, Goodman, Uhl,

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High impact information on GNB1

In the present study, we describe the isolation and nucleotide sequence analysis of the GNB1 gene promoter region [1].
Isolation and sequencing of a putative promoter region of the murine G protein beta 1 subunit (GNB1) gene [1].
Comparing the nucleotide sequence of the cDNA clone with the human genome databases using the BLAST program a region containing putative exon 1 and promoter of the human GNB1 gene in chromosome 1 was found [1].
The expression of the heterotrimeric GTP-binding protein beta 1 subunit gene (GNB1) is regulated by psychostimulants such as cocaine and amphetamines [1].
The cloning and sequence analysis of an extensive portion of the 5'-flanking regulatory region of the GNB1 gene provides new insights into the factors involved in the regulation by psychostimulants of GNB1 expression [1].

Biological context of GNB1

Since the up-regulation appears to be one of the candidate processes of sensitization, it is necessary to elucidate the cellular and molecular mechanism of the GNB1 gene regulation for a better understanding the establishment of sensitization [1].

References

Isolation and sequencing of a putative promoter region of the murine G protein beta 1 subunit (GNB1) gene. Kitanaka, J., Kitanaka, N., Takemura, M., Wang, X.B., Hembree, C.M., Goodman, N.L., Uhl, G.R. DNA Seq. (2002) [Pubmed]

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AgaP_AGAP005911	Anopheles gambiae str. PEST
AgaP_AGAP005912	Anopheles gambiae str. PEST
AGB1	Arabidopsis thaliana
GNB1	Bos taurus
gpb-1	Caenorhabditis elegans
GNB1	Canis lupus familiaris
gnb1a	Danio rerio
gnb1b	Danio rerio
Gbeta13F	Drosophila melanogaster
GNB1	Gallus gallus
GNB1	Macaca mulatta
MGG_05201	Magnaporthe oryzae 70-15
Gnb1	Mus musculus
NCU00440	Neurospora crassa OR74A
Os03g0669200	Oryza sativa Japonica Group
GNB1	Pan troglodytes
Gnb1	Rattus norvegicus
gnb1	Xenopus (Silurana) tropicalis

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