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HIST1H1E  -  histone cluster 1, H1e

Homo sapiens

Synonyms: H1.4, H1E, H1F4, H1e, H1s-4, ...
 
 
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Disease relevance of HIST1H1E

  • These results indicate that the AC inhibitor in the pancreatic cancer extract is histone H1b or H1d and histones H2A, H2B and H3 also have an AC inhibitory activity [1].
  • The AAA-->AGA codon change in H1.4 was detected only in Raji cells and was not present in a normal population or in six other cell lines derived from individuals suffering from Burkitt's lymphoma [2].
  • Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1 [3].
 

High impact information on HIST1H1E

 

Biological context of HIST1H1E

 

Anatomical context of HIST1H1E

  • With the exception of H1.2 and H1.4, we found substantial differences between the H1 mRNA levels in the different cell lines tested [9].
 

Associations of HIST1H1E with chemical compounds

 

Other interactions of HIST1H1E

  • In contrast to the differential patterns of the other subtypes, H1.2 and H1.4 were in all cells expressed at a high level, indicating a basal function compared with the other H1 histones [9].

References

  1. Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d. Yasutomo, Y., Suga, T., Wada, S., Kosano, H., Takishima, K., Mamiya, G., Kugai, N., Nagata, N. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  2. Characterization of sequence variations in human histone H1.2 and H1.4 subtypes. Sarg, B., Gréen, A., Söderkvist, P., Helliger, W., Rundquist, I., Lindner, H.H. FEBS J. (2005) [Pubmed]
  3. Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1. Lesner, A., Kartvelishvili, A., Lesniak, J., Nikolov, D., Kartvelishvili, M., Trillo-Pazos, G., Zablotna, E., Simm, M. Biochemistry (2004) [Pubmed]
  4. Changes in the protein pattern of H1 histones associated with apoptotic DNA fragmentation. Kratzmeier, M., Albig, W., Meergans, T., Doenecke, D. Biochem. J. (1999) [Pubmed]
  5. Characterization and chromatin distribution of the H1 histones and high-mobility-group non-histone chromosomal proteins of trout liver and hepatocellular carcinoma. Davie, J.R., Delcuve, G.P. Biochem. J. (1991) [Pubmed]
  6. Natural allelic variation of duck erythrocyte histone H1b. Pałyga, J., Górnicka-Michalska, E., Kowalski, A., Ksiazkiewicz, J. Int. J. Biochem. Cell Biol. (2000) [Pubmed]
  7. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Albig, W., Kardalinou, E., Drabent, B., Zimmer, A., Doenecke, D. Genomics (1991) [Pubmed]
  8. Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. Garcia, B.A., Busby, S.A., Barber, C.M., Shabanowitz, J., Allis, C.D., Hunt, D.F. J. Proteome Res. (2004) [Pubmed]
  9. Varied expression patterns of human H1 histone genes in different cell lines. Meergans, T., Albig, W., Doenecke, D. DNA Cell Biol. (1997) [Pubmed]
 
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