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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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PLA2G2E  -  phospholipase A2, group IIE

Homo sapiens

Synonyms: GIIE sPLA2, Group IIE secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 2E, sPLA2-IIE
 
 
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Disease relevance of PLA2G2E

 

High impact information on PLA2G2E

  • The enzymatic properties of recombinant human sPLA(2)-IIE were almost identical to those of sPLA(2)-IIA and IID in terms of Ca(2+) requirement, optimal pH, substrate specificity, as well as high susceptibility to the sPLA(2) inhibitor indoxam [2].
  • We also find that sPLA(2)-IIE, -V, and -X are differentially induced by kainic acid [3].
  • The distribution of sPLA(2)-IIE, V, and -X seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus [3].
 

Analytical, diagnostic and therapeutic context of PLA2G2E

  • In situ hybridization analysis revealed elevation of sPLA(2)-IIE mRNA at alveolar macrophage-like cells in the lung of endotoxin-treated mice [2].

References

  1. Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Singer, A., Gelb, M.H., Sawada, M., Inagaki, N., Nagai, H., Kudo, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. Suzuki, N., Ishizaki, J., Yokota, Y., Higashino, K., Ono, T., Ikeda, M., Fujii, N., Kawamoto, K., Hanasaki, K. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. Kolko, M., Christoffersen, N.R., Barreiro, S.G., Miller, M.L., Pizza, A.J., Bazan, N.G. J. Neurosci. Res. (2006) [Pubmed]
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