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Gene Review

HLA-DQB2  -  major histocompatibility complex, class II...

Homo sapiens

Synonyms: HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, HLA-DQB1, HLA-DXB, MHC class II antigen DQB2
 
 
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High impact information on HLA-DQB2

  • A strong association that was independent of HLA-DRB1 shared epitope alleles was observed in 2 SNPs: one in the intron of the MICA gene, the other in the intron of the HLA-DQB2 gene [1].
  • 3. YAC B1D12 spanning 320 kb contained seven of these loci from HLA-DRA to HLA-DQB2 [2].
  • Moreover, the frequently used primers for HLA-DQB1 may co-amplify the HLA-DQB2 pseudogene [3].

References

  1. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Kochi, Y., Yamada, R., Kobayashi, K., Takahashi, A., Suzuki, A., Sekine, A., Mabuchi, A., Akiyama, F., Tsunoda, T., Nakamura, Y., Yamamoto, K. Arthritis Rheum. (2004) [Pubmed]
  2. Molecular linkage of the HLA-DR, HLA-DQ, and HLA-DO genes in yeast artificial chromosomes. Kozono, H., Bronson, S.K., Taillon-Miller, P., Moorti, M.K., Jamry, I., Chaplin, D.D. Genomics (1991) [Pubmed]
  3. Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT). Pera, C., Delfino, L., Longo, A., Pistillo, M.P., Ferrara, G.B. Tissue Antigens (2000) [Pubmed]
 
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