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Gene Review:

Dppa1 - developmental pluripotency associated 1

Mus musculus

Synonyms: C77727

Maldonado-Saldivia, J. et al., Shin, M.R. et al.

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Disease relevance of Dppa1

Two of these genes were developmental pluripotency-associated gene 2 (Dppa2) and Dppa4, which we show are closely linked genes encoding putative nuclear SAP domain proteins expressed in human and mouse pluripotent stem cells and germ cell tumor-derived embryonal carcinoma cells [1].

High impact information on Dppa1

One of the downregulated genes is developmental pluripotency associated-1 (Dppa1), which has already been identified as being an Oct-4 downstream gene [2].

References

Dppa2 and Dppa4 Are Closely Linked SAP Motif Genes Restricted to Pluripotent Cells and the Germ Line. Maldonado-Saldivia, J., van den Bergen, J., Krouskos, M., Gilchrist, M., Lee, C., Li, R., Sinclair, A.H., Surani, M.A., Western, P.S. Stem Cells (2007) [Pubmed]
Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression. Shin, M.R., Cui, X.S., Jun, J.H., Jeong, Y.J., Kim, N.H. Mol. Reprod. Dev. (2005) [Pubmed]

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