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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lemd3  -  LEM domain containing 3

Mus musculus

Synonyms: AI316861, Inner nuclear membrane protein Man1, LEM domain-containing protein 3, Man1
 
 
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Disease relevance of Lemd3

  • 3) Glycans in the incomplete GPIs that accumulate in classes B and F lymphoma mutants consist of Man2- and Man3GlcN in which EthN-P is linked to Man 1 [1].
 

High impact information on Lemd3

  • Two loci linked to MPO-ANCA production on chromosomes 1 and 10 were designated Man-1 and Man-2 (for MPO-ANCA), respectively [2].
  • The GPIs in these proteins contain linear ethanolamine (EthN)-phosphate (P)-6ManManManGlcN core glycan sequences bearing an additional EthN-P attached to the Man residue (Man 1) proximal to GlcN [1].

References

  1. Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine. Hirose, S., Prince, G.M., Sevlever, D., Ravi, L., Rosenberry, T.L., Ueda, E., Medof, M.E. J. Biol. Chem. (1992) [Pubmed]
  2. Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. Hamano, Y., Tsukamoto, K., Abe, M., Sun, G.D., Zhang, D., Fujii, H., Matsuoka, S., Tanaka, M., Ishida-Okawara, A., Tachikawa, H., Nishimura, H., Tokunaka, K., Hirose, S., Suzuki, K. J. Immunol. (2006) [Pubmed]
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