The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

SFRP1  -  secreted frizzled-related protein 1

Gallus gallus

Synonyms: CsFRP1, Secreted frizzled-related protein 1, sFRP-1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SFRP1

 

High impact information on SFRP1

  • SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor [2].
  • Furthermore, retroviral mediated expression of a dominant-negative form of GSK3beta induced a retina phenotype similar to that observed after Sfrp1 overexpression, suggesting a possible involvement of this kinase in SFRP1 function [1].
  • Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development [3].
  • Here we show that Frzb-1, which encodes a secreted frizzled-related protein that can bind to Wnt proteins and can antagonize the activity of some Wnts, is expressed in the developing limb bud [4].

References

  1. SFRP1 modulates retina cell differentiation through a beta-catenin-independent mechanism. Esteve, P., Trousse, F., Rodríguez, J., Bovolenta, P. J. Cell. Sci. (2003) [Pubmed]
  2. SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor. Rodriguez, J., Esteve, P., Weinl, C., Ruiz, J.M., Fermin, Y., Trousse, F., Dwivedy, A., Holt, C., Bovolenta, P. Nat. Neurosci. (2005) [Pubmed]
  3. Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development. Terry, K., Magan, H., Baranski, M., Burrus, L.W. Mech. Dev. (2000) [Pubmed]
  4. Involvement of Frzb-1 in mesenchymal condensation and cartilage differentiation in the chick limb bud. Wada, N., Kawakami, Y., Ladher, R., Francis-West, P.H., Nohno, T. Int. J. Dev. Biol. (1999) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Use
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

WikiGenes - Universities