Gene Review:
BLNK - B-cell linker
Gallus gallus
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High impact information on BLNK
- These findings have led to the suggestion that BLNK is required for coupling Syk to PLC-gamma2, thereby accelerating cell apoptosis in B cells exposed to low doses of H2O2 [1].
- Role of BLNK in oxidative stress signaling in B cells [1].
- H2O2 treatment of B cells induced a rapid tyrosine phosphorylation of BLNK in a H2O2 dose-dependent manner, which was inhibited in Syk-deficient DT40 cells [1].
- These were derived from decreased inositol 1,4,5-trisphosphate generation through PLC-gamma2 in BLNK-deficient cells [1].
References
- Role of BLNK in oxidative stress signaling in B cells. Han, W., Takano, T., He, J., Ding, J., Gao, S., Noda, C., Yanagi, S., Yamamura, H. Antioxid. Redox Signal. (2001) [Pubmed]
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