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Gene Review:

ETV4 - ets variant 4

Gallus gallus

Ansieau, S. et al., Brent, A.E. et al., Takahashi, T. et al., Lin, J.H. et al.

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High impact information on ETV4

There is a matching in PEA3 and ER81 expression by functionally interconnected sensory and motor neurons [1].
FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression [2].
This region contains two putative Sp1 binding sites and one PU box/PEA3 motif, defined as a recognition element for members of the Ets gene family [3].

Analytical, diagnostic and therapeutic context of ETV4

Electrophoretic mobility shift assay revealed that LPS augmented the nuclear protein bindings to the Ets/PEA3 as well as kappaB motifs [4].

References

Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Lin, J.H., Saito, T., Anderson, D.J., Lance-Jones, C., Jessell, T.M., Arber, S. Cell (1998) [Pubmed]
FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Brent, A.E., Tabin, C.J. Development (2004) [Pubmed]
Identification and analysis of the chicken c-mil promoter: possible involvement of Sp1- and Ets-related proteins. Ansieau, S., Plaza, S., Ferreira, E., Dozier, C., Stéhelin, D. Genomics (1993) [Pubmed]
Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes. Takahashi, T., Sugishita, Y., Kinugawa, K., Shimizu, T., Yao, A., Harada, K., Matsui, H., Nagai, R. Mol. Cell. Biochem. (2001) [Pubmed]

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