Gene Review:
DGCR6 - DGCR6 homolog
Gallus gallus
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Disease relevance of DGCR6
- Embryos in which DGCR6 expression was attenuated revealed cardiovascular anomalies reminiscent of those found in DiGeorge syndrome [1].
High impact information on DGCR6
- We isolated the chicken ortholog of DGCR6 and showed an embryonic expression pattern that is initially broad but becomes gradually restricted to neural crest cell derivatives of the cardiovasculature [1].
References
- A chicken model for DGCR6 as a modifier gene in the DiGeorge critical region. Hierck, B.P., Molin, D.G., Boot, M.J., Poelmann, R.E., Gittenberger-de Groot, A.C. Pediatr. Res. (2004) [Pubmed]
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