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Gene Review

MDM2  -  Mdm2, p53 E3 ubiquitin protein ligase...

Canis lupus familiaris

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Disease relevance of MDM2


High impact information on MDM2

  • These results suggest that increased expression of Mdm2 is an early event in circumanal gland tumorigenesis, and may be present in the absence of nuclear p53 protein accumulation [2].
  • In 8 of the 9 tumors, mutation of p53 gene or overexpression of MDM2, or both, was detected [3].
  • With the exception of one case, a reciprocal relationship between the presence of a p53 mutation and mdm2 gene amplification was demonstrated [1].
  • Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene [4].
  • The mdm2 oncogene is amplified and overexpressed in a variety of human tumours and the oncogenic potential of MDM2 is partly due to its ability to inactivate tumour suppressor p53 function [4].

Analytical, diagnostic and therapeutic context of MDM2

  • In the present communication we describe the cloning, sequence analysis and expression of the complete wildtype canine and equine mdm2 cDNAs [4].


  1. Analysis of p53 mutational events and MDM2 amplification in canine soft-tissue sarcomas. Nasir, L., Rutteman, G.R., Reid, S.W., Schulze, C., Argyle, D.J. Cancer Lett. (2001) [Pubmed]
  2. Protein expression of Mdm2 and p53 in hyperplastic and neoplastic lesions of the canine circumanal gland. Nakano, M., Taura, Y., Inoue, M. J. Comp. Pathol. (2005) [Pubmed]
  3. Results of hyperamplification of centrosomes in naturally developing tumors of dogs. Setoguchi, A., Okuda, M., Nishida, E., Yazawa, M., Ishizaka, T., Hong, S.H., Hisasue, M., Nishimura, R., Sasaki, N., Yoshikawa, Y., Masuda, K., Ohno, K., Tsujimoto, H. Am. J. Vet. Res. (2001) [Pubmed]
  4. Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene. Nasir, L., Burr, P.D., McFarlane, S.T., Gault, E., Thompson, H., Argyle, D.J. Cancer Lett. (2000) [Pubmed]
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