Gene Review:
TNMD - tenomodulin
Gallus gallus
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High impact information on TNMD
- At stage 28, the expression profile of TeM in the axial tendons displayed more distinct morphological features at different levels of the vertebrae [1].
- Retroviral expression of Scx resulted in the significant upregulation of TeM in cultured tenocytes, but not in chondrocytes [1].
- Tenomodulin (TeM) is a type II transmembrane glycoprotein containing a C-terminal anti-angiogenic domain and is predominantly expressed in tendons and ligaments [1].
- At stage 23, when Scx expression in the syndetome has extended to the tail region, TeM was detectable in the anterior eight somites [1].
Anatomical context of TNMD
- At stage 32 and later, Scx and TeM showed similar expression profiles in developing tendons [1].
- In addition, the misexpression of RCAS-cScx by electroporation into the hindlimb could not induce the generation of additional tendons, but did result in the upregulation of TeM expression in the tendons at stage 33 and later [1].
References
- Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Shukunami, C., Takimoto, A., Oro, M., Hiraki, Y. Dev. Biol. (2006) [Pubmed]
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