High impact information on pob

• The zebrafish mutant, partial optokinetic response b (pob), was isolated using an N-ethyl N-nitrosourea (ENU)-based screening strategy designed to identify larvae with defective optokinetic responses in red but not white light [1].
• Previous studies showed that red-light blindness in pob is due to the specific loss of long-wavelength photoreceptor cells via an apoptotic mechanism [1].
• The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells [1].

Analytical, diagnostic and therapeutic context of pob

• Physiological, immunohistochemical, and in situ hybridization analyses of pob retinas showed a selective loss of red-sensitive cones at 5 days postfertilization (dpf) [2].

References