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Gene Review

LOC443413  -  GnRH receptor

Ovis aries

 
 
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High impact information on LOC443413

  • Modulation of GnRH receptor mRNA levels suggests that IN, E, and P regulate responsiveness to GnRH in the ovine pituitary at least in part by altering de novo synthesis of GnRH receptors [1].
  • The experimental paradigm comprised graded blockade of the GnRH receptor to create four distinct strata of LH and Te pulsatility in each subject [2].
  • Treatment with estradiol caused an increase in concentrations of GnRH receptor mRNA (P < 0.05) and GnRH receptors (P < 0.01) [3].
  • To explore the regulation of GnRH receptors at the level of gene expression, a partial complementary DNA (cDNA) encoding ovine GnRH receptor was isolated using reverse transcription and polymerase chain reaction methodology [4].
  • Concentrations of GnRH receptor mRNA increased 2-fold during luteolysis and were higher than control values 12 h after PGF2 alpha treatment (P < 0.05) [4].
 

Biological context of LOC443413

 

Anatomical context of LOC443413

 

Associations of LOC443413 with chemical compounds

  • After 48 h of treatment, IN or E each led to a 7- to 8-fold increase in GnRH receptor mRNA activity [1].
  • We hypothesized that during luteolysis, decreased concentrations of progesterone would be associated with increased concentrations of GnRH receptor mRNA and increased numbers of GnRH receptors [4].
  • The effect of stress-like concentrations of cortisol (C) on estrogen-dependent expression of GnRH receptor was evaluated using orchidectomized sheep (wethers; n = 6 animals per group) [13].
  • Conversely, concurrent progestin stimulation potentiated the E2-induced augmentation of tissue concentrations of GnRH receptor [14].
 

Physical interactions of LOC443413

 

Other interactions of LOC443413

 

Analytical, diagnostic and therapeutic context of LOC443413

References

  1. Hormonal regulation of gonadotropin-releasing hormone receptors and messenger RNA activity in ovine pituitary culture. Sealfon, S.C., Laws, S.C., Wu, J.C., Gillo, B., Miller, W.L. Mol. Endocrinol. (1990) [Pubmed]
  2. An ensemble model of the male gonadal axis: illustrative application in aging men. Keenan, D.M., Takahashi, P.Y., Liu, P.Y., Roebuck, P.D., Nehra, A.X., Iranmanesh, A., Veldhuis, J.D. Endocrinology (2006) [Pubmed]
  3. Regulation of gonadotropin-releasing hormone (GnRH) receptor gene expression in sheep: interaction of GnRH and estradiol. Turzillo, A.M., Nolan, T.E., Nett, T.M. Endocrinology (1998) [Pubmed]
  4. Regulation of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acid and GnRH receptors during the early preovulatory period in the ewe. Turzillo, A.M., Campion, C.E., Clay, C.M., Nett, T.M. Endocrinology (1994) [Pubmed]
  5. GnRH-receptor interaction. V. Down-regulation of pituitary receptors for GnRH in ovariectomized ewes by infusion of homologous hormone. Nett, T.M., Crowder, M.E., Moss, G.E., Duello, T.M. Biol. Reprod. (1981) [Pubmed]
  6. Are immediate early genes involved in gonadotropin-releasing hormone receptor gene regulation? Characterization of changes in GnRH receptor (GnRH-R), c-fos, and c-jun messenger ribonucleic acids during the ovine estrous cycle. Padmanabhan, V., Dalkin, A., Yasin, M., Haisenleder, D.J., Marshall, J.C., Landefeld, T.D. Biol. Reprod. (1995) [Pubmed]
  7. Regulation of ovine GnRH receptor gene expression by progesterone and oestradiol. Turzillo, A.M., Clapper, J.A., Moss, G.E., Nett, T.M. J. Reprod. Fertil. (1998) [Pubmed]
  8. Estradiol and gonadotropin-releasing hormone (GnRH) interact to increase GnRH receptor expression in ovariectomized ewes after hypothalamic-pituitary disconnection. Kirkpatrick, B.L., Esquivel, E., Moss, G.E., Hamernik, D.L., Wise, M.E. Endocrine (1998) [Pubmed]
  9. Extra- and intracellular effects of divergent selection for pituitary responsiveness to gonadotropin-releasing hormone in prepubertal ram lambs. Evans, N.P., Bramley, T.A., McNeilly, J.R., Webb, R. Biol. Reprod. (1997) [Pubmed]
  10. Pulsatile gonadotropin-releasing hormone (GnRH) increases concentrations of GnRH receptor messenger ribonucleic acid and numbers of GnRH receptors during luteolysis in the ewe. Turzillo, A.M., Juengel, J.L., Nett, T.M. Biol. Reprod. (1995) [Pubmed]
  11. Effect of prolonged exposure to oestradiol on subsequent LH secretion in ewes. Ozturk, M., Smith, R.F., Dobson, H. J. Reprod. Fertil. (1998) [Pubmed]
  12. Expression of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor in sheep spinal cord. Dolan, S., Evans, N.P., Richter, T.A., Nolan, A.M. Neurosci. Lett. (2003) [Pubmed]
  13. Effect of stress-like concentrations of cortisol on estradiol-dependent expression of gonadotropin-releasing hormone receptor in orchidectomized sheep. Adams, T.E., Sakurai, H., Adams, B.M. Biol. Reprod. (1999) [Pubmed]
  14. Concentration of GnRH receptor and GnRH receptor mRNA in pituitary tissue of orchidectomized sheep: effect of oestradiol, progesterone, and progesterone withdrawal. Sakurai, H., Adams, B.M., Adams, T.E. J. Endocrinol. (1997) [Pubmed]
  15. Comparative study between pony mares and ewes evaluating gonadotrophic response to administration of gonadotrophin-releasing hormone. Porter, M.B., Cleaver, B.D., Peltier, M., Robinson, G., Thatcher, W.W., Sharp, D.C. J. Reprod. Fertil. (1997) [Pubmed]
  16. Gonadotrope responsiveness in orchidectomized sheep: I. Effect of continuous infusion of estradiol. Sakurai, H., Adams, T.E. Biol. Reprod. (1991) [Pubmed]
 
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