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Gene Review: 

TRNE  -  tRNA

Homo sapiens

Synonyms: MT-TE, mitochondrially encoded tRNA glutamic acid, trnE
 
 
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High impact information on MT-TE

  • The chromosome 1p breakpoint was localized within a repetitive region encoding t-RNA genes, with 12A-2 (PND) as most distal and pHE2.6 (A12M2) as most proximal single-copy breakpoint flanking markers [1].
  • Here, we report on the identification of three clusters of DNA polymorphisms, one in each of the constant regions of the human T cell receptor alpha and beta gene complexes on human chromosomes 14 and 7, respectively, and a third among the human t-RNA genes on human chromosome 14 [2].
  • Other enzyme sites which were affected by (4) marginally were t-RNA and r-RNA polymerases, dihydrofolate reductase, aspartate transcarboxylase, and nucleoside kinases. d(NTP) pools of L1210 cells were reduced after 60 min [3].

References

  1. Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers. Laureys, G., Speleman, F., Versteeg, R., van der Drift, P., Chan, A., Leroy, J., Francke, U., Opdenakker, G., Van Roy, N. Oncogene (1995) [Pubmed]
  2. Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping. Nickerson, D.A., Whitehurst, C., Boysen, C., Charmley, P., Kaiser, R., Hood, L. Genomics (1992) [Pubmed]
  3. The cytotoxicity of 3-imino-1-oxoisoindolines in murine and human tissue culture cells. Hall, I.H., Wong, O.T. Anticancer Drugs (1994) [Pubmed]
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