Gene Review:
NKX2-2 - NK2 homeobox 2
Homo sapiens
Synonyms:
Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2, NKX2.2, NKX2B
- Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Smith, R., Owen, L.A., Trem, D.J., Wong, J.S., Whangbo, J.S., Golub, T.R., Lessnick, S.L. Cancer Cell (2006)
- Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. Watada, H., Mirmira, R.G., Kalamaras, J., German, M.S. Proc. Natl. Acad. Sci. U.S.A. (2000)
- FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Raum, J.C., Gerrish, K., Artner, I., Henderson, E., Guo, M., Sussel, L., Schisler, J.C., Newgard, C.B., Stein, R. Mol. Cell. Biol. (2006)
- Distinct gene expression programs function in progenitor and mature islet cells. Watada, H., Scheel, D.W., Leung, J., German, M.S. J. Biol. Chem. (2003)
- Neurogenin3 activates the islet differentiation program while repressing its own expression. Smith, S.B., Watada, H., German, M.S. Mol. Endocrinol. (2004)
- The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals. Hessabi, B., Schmidt, I., Walther, R. Biochem. Biophys. Res. Commun. (2000)
- Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1. Watada, H., Mirmira, R.G., Leung, J., German, M.S. J. Biol. Chem. (2000)
- Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Lei, Q., Jeong, Y., Misra, K., Li, S., Zelman, A.K., Epstein, D.J., Matise, M.P. Dev. Cell (2006)
- Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. Ferrari, D., Sanchez-Pernaute, R., Lee, H., Studer, L., Isacson, O. Eur. J. Neurosci. (2006)
- Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. Danesin, C., Agius, E., Escalas, N., Ai, X., Emerson, C., Cochard, P., Soula, C. J. Neurosci. (2006)
- Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Rivera, F.J., Couillard-Despres, S., Pedre, X., Ploetz, S., Caioni, M., Lois, C., Bogdahn, U., Aigner, L. Stem Cells (2006)
- Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. Ohori, Y., Yamamoto, S., Nagao, M., Sugimori, M., Yamamoto, N., Nakamura, K., Nakafuku, M. J. Neurosci. (2006)