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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NRN1  -  neuritin 1

Homo sapiens

Synonyms: NRN, Neuritin, dJ380B8.2
 
 
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High impact information on NRN1

  • Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures [1].
  • Ectopic expression of Neuritin in NIH 3T3 cells resulted in changes in cell morphology and anchorage-independent growth, whereas RDC1 ectopic expression significantly increased cell proliferation [2].
  • Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer [3].
  • Stathmin mRNA, but not neuritin or narp mRNA, which are markers for neuritic sprouting, increased in the striatum, hippocampus, and cortices after a single dose of methamphetamine [4].
 

Analytical, diagnostic and therapeutic context of NRN1

  • The complexation of six tricyclic antidepressant drugs [amitriptylin (AMN), nortriptylin (NRN), imipramin (IMN), doxepin (DXN), protriptylin (PTN), and maprotilin (MPN)] with alpha- and beta-cyclodextrins (CDs) using ion-selective electrodes (ISEs) as drug ion sensors is described [5].

References

  1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Naeve, G.S., Ramakrishnan, M., Kramer, R., Hevroni, D., Citri, Y., Theill, L.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Raggo, C., Ruhl, R., McAllister, S., Koon, H., Dezube, B.J., Früh, K., Moses, A.V. Cancer Res. (2005) [Pubmed]
  3. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. Le Jan, S., Le Meur, N., Cazes, A., Philippe, J., Le Cunff, M., Léger, J., Corvol, P., Germain, S. FEBS Lett. (2006) [Pubmed]
  4. Gene expression related to synaptogenesis, neuritogenesis, and MAP kinase in behavioral sensitization to psychostimulants. Ujike, H., Takaki, M., Kodama, M., Kuroda, S. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  5. Complexation studies of cyclodextrins with tricyclic antidepressants using ion-selective electrodes. Valsami, G.N., Koupparis, M.A., Macheras, P.E. Pharm. Res. (1992) [Pubmed]
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