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Gene Review

Jafrac2  -  thioredoxin peroxidase 2

Drosophila melanogaster

Synonyms: 1274, CG1274, DPx-4156, DPx4156, Dmel\CG1274, ...
 
 
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Disease relevance of Jafrac2

  • In contrast, TPx overexpressing cells were more susceptible to copper and heat stress when compared with control cells and exhibited DNA fragmentation [1].
 

High impact information on Jafrac2

 

Biological context of Jafrac2

 

Associations of Jafrac2 with chemical compounds

  • A thioredoxin peroxidase (TPx) that reduces H(2)O(2) was firstly characterized in the lepidopteran insect, silkworm Bombyx mori [5].

References

  1. Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Radyuk, S.N., Sohal, R.S., Orr, W.C. Biochem. J. (2003) [Pubmed]
  2. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. Tenev, T., Zachariou, A., Wilson, R., Paul, A., Meier, P. EMBO J. (2002) [Pubmed]
  3. The Thioredoxin Specificity of Drosophila GPx: A Paradigm for a Peroxiredoxin-like Mechanism of many Glutathione Peroxidases. Maiorino, M., Ursini, F., Bosello, V., Toppo, S., Tosatto, S.C., Mauri, P., Becker, K., Roveri, A., Bulato, C., Benazzi, L., De Palma, A., Floh??, L. J. Mol. Biol. (2007) [Pubmed]
  4. Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila. Rodriguez, J., Agudo, M., Van Damme, J., Vandekerckhove, J., Santarén, J.F. Eur. J. Biochem. (2000) [Pubmed]
  5. Characterization of a silkworm thioredoxin peroxidase that is induced by external temperature stimulus and viral infection. Lee, K.S., Kim, S.R., Park, N.S., Kim, I., Kang, P.D., Sohn, B.H., Choi, K.H., Kang, S.W., Je, Y.H., Lee, S.M., Sohn, H.D., Jin, B.R. Insect Biochem. Mol. Biol. (2005) [Pubmed]
 
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