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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mkrn1  -  makorin, ring finger protein, 1

Mus musculus

Synonyms: E3 ubiquitin-protein ligase makorin-1
 
 
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High impact information on Mkrn1

  • This reduction in chromosome 5-imprinted Mkrn1-p1 transcripts was proposed to destabilize the cognate chromosome 6 Mkrn1 source gene mRNA, with a partial reduction in one Mkrn1 isoform leading to the imprinted phenotype [1].
 

Biological context of Mkrn1

  • These data contradict the previous suggestions that Mkrn1-p1 is imprinted, and that either it or its source Mkrn1 gene relates to the original imprinted transgene phenotype [1].

References

  1. The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans. Gray, T.A., Wilson, A., Fortin, P.J., Nicholls, R.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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