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Gene Review:

Cep170 - centrosomal protein 170

Mus musculus

Synonyms: 4933426L22Rik, A330004A13Rik, AI195353, Centrosomal protein of 170 kDa, Kiaa0470

Guarguaglini, G. et al.

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High impact information on Cep170

We show that Cep170 labeling can be used to discriminate bona fide centriole overduplication from centriole amplification that results from aborted cell division [1].
We report the characterization of Cep170, a forkhead-associated (FHA) domain protein of previously unknown function [1].
In human cells, Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis [1].
Cep170 associates with centrosomes during interphase and with spindle microtubules during mitosis [1].

Anatomical context of Cep170

As shown by immunoelectron microscopy, Cep170 associates with subdistal appendages, typical of the mature mother centriole [1].

References

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Guarguaglini, G., Duncan, P.I., Stierhof, Y.D., Holmström, T., Duensing, S., Nigg, E.A. Mol. Biol. Cell (2005) [Pubmed]

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CEP170	Canis lupus familiaris
cep170aa	Danio rerio
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CEP170	Homo sapiens
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LOC779465	Xenopus (Silurana) tropicalis

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