Gene Review:
UGT1A4 - UDP glucuronosyltransferase 1 family,...
Homo sapiens
Synonyms:
Bilirubin-specific UDPGT isozyme 2, GNT1, HUG-BR2, UDP-glucuronosyltransferase 1-4, UDP-glucuronosyltransferase 1-D, ...
- The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers. Kurkela, M., Hirvonen, J., Kostiainen, R., Finel, M. Biochem. Pharmacol. (2004)
- Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Ehmer, U., Vogel, A., Schütte, J.K., Krone, B., Manns, M.P., Strassburg, C.P. Hepatology (2004)
- Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. Wiener, D., Fang, J.L., Dossett, N., Lazarus, P. Cancer Res. (2004)
- Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R.P., Trottier, J., Barbier, O., Ritter, J.K., Tukey, R.H. J. Biol. Chem. (2005)
- Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity. Smith, P.A., Sorich, M.J., McKinnon, R.A., Miners, J.O. J. Med. Chem. (2003)
- N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases. Malfatti, M.A., Felton, J.S. Carcinogenesis (2001)
- Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Li, Q., Lamb, G., Tukey, R.H. Mol. Pharmacol. (2000)
- Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms. Nakajima, M., Tanaka, E., Kobayashi, T., Ohashi, N., Kume, T., Yokoi, T. Drug Metab. Dispos. (2002)
- Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Green, M.D., King, C.D., Mojarrabi, B., Mackenzie, P.I., Tephly, T.R. Drug Metab. Dispos. (1998)
- Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human udp-glucuronosyltransferases. Uchaipichat, V., Mackenzie, P.I., Elliot, D.J., Miners, J.O. Drug Metab. Dispos. (2006)
- UDPGT cDNA expression and UDPGT1 in human liver. Sheen, Y.Y., Owens, I.S., Kim, S.S., Kim, J.E. The Journal of toxicological sciences. (1998)
- Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Kaku, T., Ogura, K., Nishiyama, T., Ohnuma, T., Muro, K., Hiratsuka, A. Biochem. Pharmacol. (2004)
- Isolation of the UDP-Glucuronosyltransferase 1A3 and 1A4 Proximal Promoters and Characterization of Their Dependence on the Transcription Factor Hepatocyte Nuclear Factor 1{alpha}. Gardner-Stephen, D.A., Mackenzie, P.I. Drug Metab. Dispos. (2007)
- Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s). Kaji, H., Kume, T. Drug Metab. Dispos. (2005)
- N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. Ghosheh, O., Hawes, E.M. Drug Metab. Dispos. (2002)
- N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases. Kuehl, G.E., Murphy, S.E. Drug Metab. Dispos. (2003)
- Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes. Nakajima, M., Sakata, N., Ohashi, N., Kume, T., Yokoi, T. Drug Metab. Dispos. (2002)
- Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. Ogura, K., Ishikawa, Y., Kaku, T., Nishiyama, T., Ohnuma, T., Muro, K., Hiratsuka, A. Biochem. Pharmacol. (2006)
- Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity. Finel, M., Li, X., Gardner-Stephen, D., Bratton, S., Mackenzie, P.I., Radominska-Pandya, A. J. Pharmacol. Exp. Ther. (2005)
- Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Bruck, M., Li, Q., Lamb, J.G., Tukey, R.H. Arch. Biochem. Biophys. (1997)
- UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Mori, A., Maruo, Y., Iwai, M., Sato, H., Takeuchi, Y. Drug Metab. Dispos. (2005)
- Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. Sun, D., Chen, G., Dellinger, R.W., Duncan, K., Fang, J.L., Lazarus, P. Breast Cancer Res. (2006)