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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gpr97  -  G protein-coupled receptor 97

Mus musculus

Synonyms: A030001G24Rik, AW214383, Pb1, Pb99
 
 
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High impact information on Gpr97

  • Here we report the isolation of full-length cDNAs and genomic clones for the murine Pb99 gene and the mapping of its location to mouse chromosome 8 [1].
  • To directly address the role of the Pb99 protein in lymphoid development, Pb99-deficient mice were generated by gene targeting, and lymphocyte development in these mice was analyzed [1].
  • The Pb99 gene is specifically expressed in pre-B cells and thymocytes and not in mature B and T cells or nonlymphoid tissues, implying that it may function in early lymphoid development [1].
 

Analytical, diagnostic and therapeutic context of Gpr97

  • Sequence analyses of different Pb99 cDNA clones suggest that there may be at least three forms of the Pb99 protein generated by differential processing of the Pb99 transcript [1].

References

  1. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Sleckman, B.P., Khan, W.N., Xu, W., Bassing, C.H., Malynn, B.A., Copeland, N.G., Bardon, C.G., Breit, T.M., Davidson, L., Oltz, E.M., Jenkins, N.A., Berman, J.E., Alt, F.W. Mol. Cell. Biol. (2000) [Pubmed]
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