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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Eif3i  -  eukaryotic translation initiation factor 3...

Mus musculus

Synonyms: 36kDa, D4Ertd632e, Eif3s2, Eukaryotic translation initiation factor 3 subunit 2, Eukaryotic translation initiation factor 3 subunit I, ...
 
 
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Disease relevance of Eif3s2

  • The mAbs which recognised 42 and 36kDa parasite protein, reacted with Nc-p43 and Nc-p36 expressed by vaccinia virus and Escherichia coli, respectively [1].
 

High impact information on Eif3s2

  • We have previously shown that a WD-40 repeat protein, TRIP-1, associates with the type II transforming growth factor beta (TGF-beta) receptor [2].
  • Here we demonstrate that Lyn interacts with thyroid hormone receptor-interacting protein 1 (Trip-1), a transcriptional regulator associated with the T(3) receptor, providing a link between the Epo and T(3) signaling pathways [3].
  • Strikingly, a truncated Trip-1 inhibited both erythropoietin-induced maturation and T(3)-initiated cell division [3].
  • This mutant Trip-1 acted in a dominant negative fashion by eliminating endogenous Lyn, elevating p27(Kip1), and blocking T(3) response elements [3].
  • Karyotypic analysis of 21 clones showed that the expression of TPI and chromosome 6 were concordant in all cases as was expressed of TRIP-1 and chromosome 10 [4].

References

  1. Monoclonal antibody inhibition of Neospora caninum tachyzoite invasion into host cells. Nishikawa, Y., Xuan, X., Nagasawa, H., Igarashi, I., Fujisaki, K., Otsuka, H., Mikami, T. Int. J. Parasitol. (2000) [Pubmed]
  2. Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Griswold-Prenner, I., Kamibayashi, C., Maruoka, E.M., Mumby, M.C., Derynck, R. Mol. Cell. Biol. (1998) [Pubmed]
  3. Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells. Ingley, E., Chappell, D., Poon, S.Y., Sarna, M.K., Beaumont, J.G., Williams, J.H., Stillitano, J.P., Tsai, S., Leedman, P.J., Tilbrook, P.A., Klinken, S.P. J. Biol. Chem. (2001) [Pubmed]
  4. Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization. Leinwand, L.A., Kozak, C.A., Ruddle, F.H. Somatic Cell Genet. (1978) [Pubmed]
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