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UACA  -  uveal autoantigen with coiled-coil domains...

Homo sapiens

Synonyms: FLJ10128, KIAA1561, Uveal autoantigen with coiled-coil domains and ankyrin repeats
 
 
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Disease relevance of UACA

 

High impact information on UACA

  • The highest affinity RNA sequences (Kd approximately 12-40 nM) contained a UAAA motif; mutation to UACA abolished binding to Sam68 [2].
  • Originally, UACA was cloned from dog thyroid tissue following TSH stimulation [1].
  • So, we presumed UACA could be a novel autoantigen in autoimmune thyroid diseases [1].
  • The prevalence of IgG anti-UACA autoantibodies in patients with panuveitis (Vogt-Koyanagi-Harada disease, Behçet's disease, sarcoidosis) was significantly higher than that in healthy controls (19.6-28.1% vs 0%, P < 0.05) indicating that autoimmunity directed against UACA is a common phenomenon in these diseases [3].
  • METHODS AND RESULTS: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 +/- 16 years [mean +/- SD]) with UACAP [4].
 

Analytical, diagnostic and therapeutic context of UACA

  • IgG autoantibodies were quantitated in an ELISA, using recombinant C-terminal 18.0% fragment of human UACA [3].

References

  1. Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease. Ohkura, T., Taniguchi, S., Yamada, K., Nishio, N., Okamura, T., Yoshida, A., Kamijou, K., Fukata, S., Kuma, K., Inoue, Y., Hisatome, I., Senju, S., Nishimura, Y., Shigemasa, C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains. Lin, Q., Taylor, S.J., Shalloway, D. J. Biol. Chem. (1997) [Pubmed]
  3. Identification of a novel autoantigen UACA in patients with panuveitis. Yamada, K., Senju, S., Nakatsura, T., Murata, Y., Ishihara, M., Nakamura, S., Ohno, S., Negi, A., Nishimura, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Effect of isoproterenol on accessory pathways without overt retrograde conduction. Li, H.G., Yee, R., Klein, G.J. J. Cardiovasc. Electrophysiol. (1995) [Pubmed]
 
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