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Gene Review: 

FAIM  -  Fas apoptotic inhibitory molecule

Homo sapiens

Synonyms: FAIM1, FLJ10582, Fas apoptotic inhibitory molecule 1
 
 
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High impact information on FAIM

  • A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes [1].
  • However, faim is broadly expressed in various tissues and the faim sequence is highly conserved evolutionarily, suggesting that its role extends beyond lymphocyte homeostasis [1].
  • The effect of FAIM on neurite outgrowth was also blocked by inhibition of the Ras-ERK pathway [2].
  • Proximate mediators for Fas resistance include the known anti-apoptotic gene products Bcl-xL and FLIP (but not Btk), and a novel anti-apoptotic gene that encodes Fas apoptosis inhibitory molecule (FAIM) [3].
  • FAIM was identified by differential display and was cloned as two alternatively spliced forms: FAIM-S is broadly expressed, whereas faim-L expression is tissue specific. faim is highly evolutionarily conserved, suggesting an important function throughout phylogeny [3].
 

Biological context of FAIM

  • The FAIM sequence is highly evolu- tionarily conserved, suggesting an important role for this molecule throughout phylogeny [4].
  • The murine FAIM gene is located at chromosome 9f1, a region syntenic to the corresponding location of the human FAIM gene [5].
  • The long form of FAIM is generated by all six exons, whereas the originally cloned form of FAIM, now termed FAIM-Short (FAIM-S) is generated from five exons by alternative splicing [5].
 

Anatomical context of FAIM

  • Thus, FAIM is an inducible effector molecule that mediates Fas resistance produced by sIg engagement in B cells [1].
  • Two were CHO GT(O) cell lines overexpressing anti-apoptotic genes, Faim and Fadd DN and two were CHO GT(KD) cell lines involving knockdown of Alg-2 and Requiem which are pro-apoptotic genes using small interfering RNA (siRNA) technology [6].
 

Associations of FAIM with chemical compounds

  • This paper aims to contribute to the current debate on cash-based interventions by drawing on the experience of Action Contre la Faim in southern Somalia, where it has implemented cash for work programmes since 2004 [7].

References

  1. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. Schneider, T.J., Fischer, G.M., Donohoe, T.J., Colarusso, T.P., Rothstein, T.L. J. Exp. Med. (1999) [Pubmed]
  2. The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. Sole, C., Dolcet, X., Segura, M.F., Gutierrez, H., Diaz-Meco, M.T., Gozzelino, R., Sanchis, D., Bayascas, J.R., Gallego, C., Moscat, J., Davies, A.M., Comella, J.X. J. Cell Biol. (2004) [Pubmed]
  3. Receptor-specific regulation of B-cell susceptibility to Fas-mediated apoptosis and a novel Fas apoptosis inhibitory molecule. Rothstein, T.L., Zhong, X., Schram, B.R., Negm, R.S., Donohoe, T.J., Cabral, D.S., Foote, L.C., Schneider, T.J. Immunol. Rev. (2000) [Pubmed]
  4. Inducible resistance to Fas-mediated apoptosis in B cells. Rothstein, T.L. Cell Res. (2000) [Pubmed]
  5. An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain. Zhong, X., Schneider, T.J., Cabral, D.S., Donohoe, T.J., Rothstein, T.L. Mol. Immunol. (2001) [Pubmed]
  6. Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Wong, D.C., Wong, K.T., Nissom, P.M., Heng, C.K., Yap, M.G. Biotechnol. Bioeng. (2006) [Pubmed]
  7. Cash-based interventions: lessons from southern Somalia. Mattinen, H., Ogden, K. Disasters. (2006) [Pubmed]
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