High impact information on C1qtnf1

• The putative transmembrane and cytoplasmic regions of PbCTRP, CTRP, and TRAP also have conserved amino acid sequences [1].
• We show that transgenic parasites in which the CTRP gene is disrupted form ookinetes that have reduced motility, fail to invade the midgut epithelium, do not trigger the mosquito immune response, and do not develop further into oocysts [2].
• Although most macrophage colonies did not contain CTRP, no CTRP were observed in colonies from which macrophages were absent [3].
• Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue [4].
• Moreover, spleen stromal cells were equivalent to bone marrow stromal cells in CTRP-cell induction [5].

Anatomical context of C1qtnf1

• These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues [4].
• The spleen CTRP cells did not resorb bone, but were rapidly induced to full resorptive activity upon osteoblast addition [5].

Associations of C1qtnf1 with chemical compounds

• We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3, in cultures of hemopoietic mouse spleen [5].

References