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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SPIRE1  -  spire-type actin nucleation factor 1

Homo sapiens

Synonyms: KIAA1135, Protein spire homolog 1, SPIR1, Spir-1, spir-1
 
 
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High impact information on SPIRE1

  • The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation [1].
  • RESULTS: Alcohol companies spent 590.4 million US dollars to place 471 beer and ale advertisements (8%), 4748 distilled spir-its advertisements (76%), 116 low-alcohol refresher advertisements (2%), and 904 advertisements for wine (14%) in magazines in 2001 and 2002 [2].
  • By analyzing the expression of the spir-1 gene we show that spir-1 and formin-2 have a nearly identical expression pattern during mouse embryogenesis and in the adult brain [3].
  • Mammalian homologues of spire are the spir-1 and spir-2 genes [3].

References

  1. Actin nucleation: spire - actin nucleator in a class of its own. Baum, B., Kunda, P. Curr. Biol. (2005) [Pubmed]
  2. Sex differences in adolescent exposure to alcohol advertising in magazines. Jernigan, D.H., Ostroff, J., Ross, C., O'Hara, J.A. Archives of pediatrics & adolescent medicine. (2004) [Pubmed]
  3. Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain. Schumacher, N., Borawski, J.M., Leberfinger, C.B., Gessler, M., Kerkhoff, E. Gene Expr. Patterns (2004) [Pubmed]
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