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Gene Review:

Olfr1507 - olfactory receptor 1507

Mus musculus

Synonyms: GA_x6K02T2RJGY-491851-492792, MOR244-1, MOR28, Mor28, Or28

Sengoku, S. et al., Serizawa, S. et al., Nakatani, H. et al., Ishii, T. et al., Tsuboi, A. et al., et al.

Nagawa, Yoshihara, Tsuboi, Serizawa, Itoh, Sakano,

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High impact information on Olfr1507

Expression of the transgene and the endogenous MOR28 was distinguished by using two different markers, beta-galactosidase and green fluorescent protein (GFP), respectively [1].
Using the yeast artificial chromosome (YAC) transgenic system, we have analysed the expression of the murine OR gene MOR29A of the MOR28 cluster located on chromosome 14 [2].
Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map [3].
RESULTS: Our fluorescent in situ hybridization (FISH) revealed that the two endogenous alleles of MOR28 are also mutually excluded for their transcriptional activation [4].
We have found that the axon terminals of the two sets of MOR28-positive OSNs, one expressing the lacZ tag and the other expressing the green fluorescent protein gene, are dispersed and intermingled at early developmental or regeneration stages [5].

Biological context of Olfr1507

Murine OR genes, MOR28, MOR10, and MOR83, share 75-95% similarities in the amino acid sequences and are tightly linked on chromosome 14 [6].

Anatomical context of Olfr1507

We have studied the projection of olfactory sensory neurons (OSNs), during the developmental and regeneration processes, using the transgenic mouse carrying the differently tagged odorant receptor genes, MOR28 [5].

References

Mutually exclusive expression of odorant receptor transgenes. Serizawa, S., Ishii, T., Nakatani, H., Tsuboi, A., Nagawa, F., Asano, M., Sudo, K., Sakagami, J., Sakano, H., Ijiri, T., Matsuda, Y., Suzuki, M., Yamamori, T., Iwakura, Y., Sakano, H. Nat. Neurosci. (2000) [Pubmed]
Developmental elimination of ectopic projection sites for the transgenic OR gene that has lost zone specificity in the olfactory epithelium. Nakatani, H., Serizawa, S., Nakajima, M., Imai, T., Sakano, H. Eur. J. Neurosci. (2003) [Pubmed]
Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map. Nagawa, F., Yoshihara, S., Tsuboi, A., Serizawa, S., Itoh, K., Sakano, H. Gene (2002) [Pubmed]
Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones. Ishii, T., Serizawa, S., Kohda, A., Nakatani, H., Shiroishi, T., Okumura, K., Iwakura, Y., Nagawa, F., Tsuboi, A., Sakano, H. Genes Cells (2001) [Pubmed]
Axonal projection of olfactory sensory neurons during the developmental and regeneration processes. Sengoku, S., Ishii, T., Serizawa, S., Nakatani, H., Nagawa, F., Tsuboi, A., Sakano, H. Neuroreport (2001) [Pubmed]
Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb. Tsuboi, A., Yoshihara, S., Yamazaki, N., Kasai, H., Asai-Tsuboi, H., Komatsu, M., Serizawa, S., Ishii, T., Matsuda, Y., Nagawa, F., Sakano, H. J. Neurosci. (1999) [Pubmed]

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