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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fbxo3  -  F-box protein 3

Mus musculus

Synonyms: 1200002G09Rik, 1700026K02Rik, AI046358, F-box only protein 3, Fba, ...
 
 
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High impact information on Fbxo3

  • These results indicate that Fba is a novel protein and one of the important virulence factors of S. pyogenes [1].
  • After searching the Oklahoma Streptococcal Genome Sequencing Database for open reading frames (ORFs) with an LPXTG motif, nine ORFs were found among those recognized as putative surface proteins, and one of them was designated as Fba [1].
  • Fba has been shown to contribute to phagocytosis resistance, intracellular invasion, and virulence in mice [2].

References

  1. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Terao, Y., Kawabata, S., Kunitomo, E., Murakami, J., Nakagawa, I., Hamada, S. Mol. Microbiol. (2001) [Pubmed]
  2. Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes. Wei, L., Pandiripally, V., Gregory, E., Clymer, M., Cue, D. Infect. Immun. (2005) [Pubmed]
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