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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pias4  -  protein inhibitor of activated STAT 4

Mus musculus

Synonyms: E3 SUMO-protein ligase PIAS4, PIAS-gamma, PIASY, PIASy, Pias-gamma, ...
 
 
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Disease relevance of Pias4

 

High impact information on Pias4

  • Activation of STAT1 is not significantly perturbed in Piasy(-/-) cells, and sumoylation patterns for SUMO-1 or SUMO-3 modification are similar when comparing tissues and embryonic fibroblasts from wild-type and knockout mice [2].
  • Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life [2].
  • Overexpressed TRAF7 was localized in the cytoplasm of CV-1 cells, and sequestered c-Myb and SUMO1 in the cytosol, whereas PIASy was localized in the nucleus [3].
  • In particular, PIASy has been shown to inhibit the activation of gene expression by the IFN-responsive transcription factor STAT1 and the Wnt-responsive transcription factor LEF1 [4].

References

  1. Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation. Tahk, S., Liu, B., Chernishof, V., Wong, K.A., Wu, H., Shuai, K. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Wong, K.A., Kim, R., Christofk, H., Gao, J., Lawson, G., Wu, H. Mol. Cell. Biol. (2004) [Pubmed]
  3. TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Morita, Y., Kanei-Ishii, C., Nomura, T., Ishii, S. Mol. Biol. Cell (2005) [Pubmed]
  4. PIASy-deficient mice display modest defects in IFN and Wnt signaling. Roth, W., Sustmann, C., Kieslinger, M., Gilmozzi, A., Irmer, D., Kremmer, E., Turck, C., Grosschedl, R. J. Immunol. (2004) [Pubmed]
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