Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Zfp191 - zinc finger protein 191

Mus musculus

Synonyms: 3526401F17Rik, 5033419P20Rik, AI480505, AI642085, AL024422, ...

Li, J. et al., Prost, J.F. et al.

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High impact information on Zfp191

Zfp191 is widely expressed during embryonic development and in multiple tissues and organs in adult [1].
In further agreement with this function, no viable Zfp191(-/-) cell lines were obtained by derivation of embryonic stem (ES) cells from blastocysts of Zfp191(+/-) intercrosses or by forced homogenotization of heterozygous ES cells at high concentrations of G418 [1].
Unexpectedly, in Zfp191(-/-) and Zfp191(+/-) embryos, TH gene expression is not affected [1].
Blastocyst outgrowth experiments and the RNA interference-mediated knockdown of ZNF191 in cultured cells revealed an essential role for Zfp191 in cell proliferation [1].
The predicted 368-amino acid protein, designated ZF-12, contains four C(2)H(2)-type zinc finger motifs and one region homologous to the LeR domain, a finger-associated structural domain [2].

Biological context of Zfp191

ZF-12 mRNAs are expressed during embryonic development and in different organs in adult, including rib cartilage [2].

References

The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation. Li, J., Chen, X., Yang, H., Wang, S., Guo, B., Yu, L., Wang, Z., Fu, J. Exp. Cell Res. (2006) [Pubmed]
Isolation, cloning, and expression of a new murine zinc finger encoding gene. Prost, J.F., Nègre, D., Cornet-Javaux, F., Cortay, J.C., Cozzone, A.J., Herbage, D., Mallein-Gerin, F. Biochim. Biophys. Acta (1999) [Pubmed]

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