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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SENP2  -  SUMO1/sentrin/SMT3 specific peptidase 2

Homo sapiens

Synonyms: AXAM2, Axam2, DKFZp762A2316, KIAA1331, SMT3-specific isopeptidase 2, ...
 
 
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Disease relevance of SENP2

  • The SMT3IP2 expressed by Escherichia coli could cleave SUMO-1, Smt3a, or Smt3b from a SUMO-1/RanGAP1, Smt3a/RanGAP1, or Smt3b/RanGAP1 conjugate, respectively, and had the activity of a carboxyl-terminal hydrolase to produce a glycine residue in the carboxyl terminus of these ubiquitin-like proteins [1].
 

High impact information on SENP2

References

  1. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. Nishida, T., Kaneko, F., Kitagawa, M., Yasuda, H. J. Biol. Chem. (2001) [Pubmed]
  2. Association of the human SUMO-1 protease SENP2 with the nuclear pore. Hang, J., Dasso, M. J. Biol. Chem. (2002) [Pubmed]
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