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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RFX3  -  regulatory factor X, 3 (influences HLA...

Homo sapiens

Synonyms: Regulatory factor X 3, Transcription factor RFX3
 
 
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Disease relevance of RFX3

 

High impact information on RFX3

  • In other cell lines and tissues, RFX mRNA levels are variable, particularly for RFX2 and RFX3 [2].
  • RFX3 expression already is evident in early Ngn3-positive progenitors and is maintained in all major pancreatic endocrine cell lineages throughout their development [3].
  • These findings suggest that RFX3 participates in the mechanisms that govern pancreatic endocrine cell differentiation and that the presence of primary cilia on islet cells may play a key role in this process [3].
  • RFX3 is expressed strongly in the ciliated ependymal cells of the subcommissural organ (SCO), choroid plexuses (CP) and ventricular walls during embryonic and postnatal development [1].
  • We showed that in vitro-translated RFX3, as well as RFX1 and RFX2, was able to bind B10.RRE in a sequence-specific manner [4].

References

  1. A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells. Baas, D., Meiniel, A., Benadiba, C., Bonnafe, E., Meiniel, O., Reith, W., Durand, B. Eur. J. Neurosci. (2006) [Pubmed]
  2. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Reith, W., Ucla, C., Barras, E., Gaud, A., Durand, B., Herrero-Sanchez, C., Kobr, M., Mach, B. Mol. Cell. Biol. (1994) [Pubmed]
  3. Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas. Ait-Lounis, A., Baas, D., Barras, E., Benadiba, C., Charollais, A., Nlend Nlend, R., Liègeois, D., Meda, P., Durand, B., Reith, W. Diabetes (2007) [Pubmed]
  4. Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Maijgren, S., Sur, I., Nilsson, M., Toftgård, R. Arch. Dermatol. Res. (2004) [Pubmed]
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