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RFX2  -  regulatory factor X, 2 (influences HLA...

Homo sapiens

Synonyms: DNA-binding protein RFX2, FLJ14226, Regulatory factor X 2
 
 
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High impact information on RFX2

  • RFX2 belongs to the RFX DNA-binding protein family, the biological role of which remains obscure [1].
  • They have very similar DNA-binding specificities and heterodimerize both in vitro and in vivo. mRNA levels for all three genes, particularly RFX2, are elevated in testis [2].
  • We also showed that RFX2 activated the H1t promoter in transient expression assays [3].
  • Testis RFX2 is most abundant in spermatocytes where transcription of the H1t gene is upregulated and the steady-state H1t mRNA level is high [3].
  • RFX2 levels decrease but RFX1 levels increase in early spermatids where H1t gene transcription is downregulated [3].
 

Biological context of RFX2

 

Anatomical context of RFX2

 

Other interactions of RFX2

  • Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins [4].
  • We showed that in vitro-translated RFX3, as well as RFX1 and RFX2, was able to bind B10.RRE in a sequence-specific manner [6].
 

Analytical, diagnostic and therapeutic context of RFX2

  • Using the H1t X-box as an affinity chromatography probe, we identified Regulatory Factor X2 (RFX2), a member of the RFX family of transcription factors, as a nuclear protein that binds the probe [3].

References

  1. Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. Iwama, A., Pan, J., Zhang, P., Reith, W., Mach, B., Tenen, D.G., Sun, Z. Mol. Cell. Biol. (1999) [Pubmed]
  2. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Reith, W., Ucla, C., Barras, E., Gaud, A., Durand, B., Herrero-Sanchez, C., Kobr, M., Mach, B. Mol. Cell. Biol. (1994) [Pubmed]
  3. Transcription factor RFX2 is abundant in rat testis and enriched in nuclei of primary spermatocytes where it appears to be required for transcription of the testis-specific histone H1t gene. Wolfe, S.A., van Wert, J., Grimes, S.R. J. Cell. Biochem. (2006) [Pubmed]
  4. Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. Doyle, J., Hoffman, S., Ucla, C., Reith, W., Mach, B., Stubbs, L. Genomics (1996) [Pubmed]
  5. The RFX family interacts at the collagen (COL1A2) start site and represses transcription. Sengupta, P.K., Fargo, J., Smith, B.D. J. Biol. Chem. (2002) [Pubmed]
  6. Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Maijgren, S., Sur, I., Nilsson, M., Toftgård, R. Arch. Dermatol. Res. (2004) [Pubmed]
 
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