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Gene Review

MRPL23  -  mitochondrial ribosomal protein L23

Homo sapiens

Synonyms: 39S ribosomal protein L23, mitochondrial, L23 mitochondrial-related protein, L23MRP, L23mt, MRP-L23, ...
 
 
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High impact information on MRPL23

  • 5. We previously described biallelic expression of L23MRP, 40 kb downstream of H19 [1].
  • Here we map two additional genes, the first encoding a ubiquitously expressed RNA, 2G7, and the second encoding the fast isoform of skeletal muscle troponin-T (TNNT3), in the 55 kb of DNA downstream of L23MRP [1].
  • Cosmid, P1, PAC, and BAC clones were characterized by NotI/SalI digestion and hybridized to a variety of probes to generate a detailed physical map that extends from D11S517 to L23MRP [2].
  • In rice, a ribosomal protein gene cluster, rpl23-rpl2-rps19, which codes for the ribosomal proteins L23 (rpl23), L2 (rpl2) and S19 (rps19), lies at the ends of the two IRs near the LSCR [3].
  • In individual analyses of the alignments, only two probable examples of lateral gene transfer between archaea and eubacteria were detected, involving the genes for ribosomal protein Rpl23 and adenylate kinase [4].
 

Biological context of MRPL23

  • The DNA sequence shared by S10A and S10B includes trnI1, the rpl23 pseudogene (rpl23 psi), the intron-containing rpl2 and rps19, which is truncated in S10A at the S10A/LSC junction (rps19') [5].
  • Here we hypothesize a total loss of rpl2 and rpl23 in the entire genome of C. reflexa [6].
 

Other interactions of MRPL23

  • These data indicate that, at least in post-embryonic stages, L23MRP is functionally insulated from the IGF2/H19 imprinted domain [7].

References

  1. An extended region of biallelic gene expression and rodent-human synteny downstream of the imprinted H19 gene on chromosome 11p15.5. Yuan, L., Qian, N., Tycko, B. Hum. Mol. Genet. (1996) [Pubmed]
  2. A 1-Mb physical map and PAC contig of the imprinted domain in 11p15.5 that contains TAPA1 and the BWSCR1/WT2 region. Reid, L.H., Davies, C., Cooper, P.R., Crider-Miller, S.J., Sait, S.N., Nowak, N.J., Evans, G., Stanbridge, E.J., deJong, P., Shows, T.B., Weissman, B.E., Higgins, M.J. Genomics (1997) [Pubmed]
  3. Organization and nucleotide sequence of genes at both junctions between the two inverted repeats and the large single-copy region in the rice chloroplast genome. Moon, E., Wu, R. Gene (1988) [Pubmed]
  4. Phylogeny of 33 ribosomal and six other proteins encoded in an ancient gene cluster that is conserved across prokaryotic genomes: influence of excluding poorly alignable sites from analysis. Hansmann, S., Martin, W. Int. J. Syst. Evol. Microbiol. (2000) [Pubmed]
  5. Differential expression of the partially duplicated chloroplast S10 ribosomal protein operon. Tonkyn, J.C., Gruissem, W. Mol. Gen. Genet. (1993) [Pubmed]
  6. A large deletion in the plastid DNA of the holoparasitic flowering plant Cuscuta reflexa concerning two ribosomal proteins (rpl2, rpl23), one transfer RNA (trnI) and an ORF 2280 homologue. Bömmer, D., Haberhausen, G., Zetsche, K. Curr. Genet. (1993) [Pubmed]
  7. A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues. Tsang, P., Gilles, F., Yuan, L., Kuo, Y.H., Lupu, F., Samara, G., Moosikasuwan, J., Goye, A., Zelenetz, A.D., Selleri, L. Hum. Mol. Genet. (1995) [Pubmed]
 
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