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Gene Review

ZNF674  -  zinc finger protein 674

Homo sapiens

Synonyms: MRX92, ZNF673B, Zinc finger protein 674
 
 
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Disease relevance of ZNF674

  • These genes were analyzed in 28 families with nonsyndromic X-linked mental retardation (XLMR) that show linkage to Xp11.3; the analysis revealed a nonsense mutation, p.E118X, in the coding sequence of ZNF674 in one family [1].
 

High impact information on ZNF674

  • The p.T343M transition is probably a polymorphism, because the homologous ZNF674 gene in chimpanzee has a methionine at that position [1].
  • Identification of ZNF674 as the third XLMR gene in this cluster may indicate a common role for these zinc-finger genes that is crucial to human cognitive functioning [1].
  • The proline at position 412 is conserved between species and is predicted by molecular modeling to reduce the DNA-binding properties of ZNF674 [1].

References

  1. ZNF674: A New Kruppel-Associated Box-Containing Zinc-Finger Gene Involved in Nonsyndromic X-Linked Mental Retardation. Lugtenberg, D., Yntema, H.G., Banning, M.J., Oudakker, A.R., Firth, H.V., Willatt, L., Raynaud, M., Kleefstra, T., Fryns, J.P., Ropers, H.H., Chelly, J., Moraine, C., Gecz, J., Reeuwijk, J., Nabuurs, S.B., de Vries, B.B., Hamel, B.C., de Brouwer, A.P., Bokhoven, H. Am. J. Hum. Genet. (2006) [Pubmed]
 
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