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ABCG4  -  ATP-binding cassette, sub-family G (WHITE)...

Homo sapiens

Synonyms: ATP-binding cassette sub-family G member 4, WHITE2
 
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High impact information on ABCG4

 

Biological context of ABCG4

  • ABCG4 maps to human chromosome 11q23, between the markers D11S939 and D11S924, and Abcg4 to a conserved syntenic region on mouse chromosome 9 [4].
  • Analysis of the genomic organization demonstrates that the ABCG4 gene is composed of at least 14 exons which extend across a region of 12.6 kb in size on chromosome 11q23 [3].
  • The cloned ABCG4 transcript has a size of 3.5 kb and contains an open reading frame which encodes a polypeptide of 646 amino acids [3].
  • We expressed ABCG1 and ABCG4 and their catalytic site mutant variants in insect cells, generated specific antibodies, and analyzed their function in isolated membrane preparations [5].
  • Since dimerization is a requirement for half-transporters, we suggest that both ABCG1 and ABCG4 function as homodimers [5].
 

Anatomical context of ABCG4

  • In this test, Congo red and methylene blue sprayed on the surface of the tumor were bleached white 2 to 5 minutes after application, in sharp contrast to the unaffected mucosa [6].
 

Associations of ABCG4 with chemical compounds

  • The abundant expression of this gene in the brain and close evolutionary relationship to the other members of the subfamily suggests a potential role for ABCG4 in cholesterol transport processes in this tissue [4].
 

Other interactions of ABCG4

  • ABCG4: a novel human white family ABC-transporter expressed in the brain and eye [7].
 

Analytical, diagnostic and therapeutic context of ABCG4

References

  1. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Wang, N., Lan, D., Chen, W., Matsuura, F., Tall, A.R. Proc. Natl. Acad. Sci. U.S.A. (2004)
  2. Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. Yoshikawa, M., Yabuuchi, H., Kuroiwa, A., Ikegami, Y., Sai, Y., Tamai, I., Tsuji, A., Matsuda, Y., Yoshida, H., Ishikawa, T. Gene (2002)
  3. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. Engel, T., Lorkowski, S., Lueken, A., Rust, S., Schlüter, B., Berger, G., Cullen, P., Assmann, G. Biochem. Biophys. Res. Commun. (2001)
  4. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Annilo, T., Tammur, J., Hutchinson, A., Rzhetsky, A., Dean, M., Allikmets, R. Cytogenet. Cell Genet. (2001)
  5. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Cserepes, J., Szentpétery, Z., Seres, L., Ozvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi, B., Elkind, N.B. Biochem. Biophys. Res. Commun. (2004)
  6. Diagnosis of early gastric cancers in the upper part of the stomach by the endoscopic Congo red-methylene blue test. Tatsuta, M., Iishi, H., Okuda, S., Taniguchi, H. Endoscopy. (1984)
  7. ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. Oldfield, S., Lowry, C., Ruddick, J., Lightman, S. Biochim. Biophys. Acta (2002)
 

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