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ABCG4  -  ATP-binding cassette, sub-family G (WHITE)...

Homo sapiens

Synonyms: ATP-binding cassette sub-family G member 4, WHITE2
 
 
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High impact information on ABCG4

 

Biological context of ABCG4

  • ABCG4 maps to human chromosome 11q23, between the markers D11S939 and D11S924, and Abcg4 to a conserved syntenic region on mouse chromosome 9 [4].
  • Analysis of the genomic organization demonstrates that the ABCG4 gene is composed of at least 14 exons which extend across a region of 12.6 kb in size on chromosome 11q23 [3].
  • The cloned ABCG4 transcript has a size of 3.5 kb and contains an open reading frame which encodes a polypeptide of 646 amino acids [3].
  • We expressed ABCG1 and ABCG4 and their catalytic site mutant variants in insect cells, generated specific antibodies, and analyzed their function in isolated membrane preparations [5].
  • Since dimerization is a requirement for half-transporters, we suggest that both ABCG1 and ABCG4 function as homodimers [5].
 

Anatomical context of ABCG4

  • In this test, Congo red and methylene blue sprayed on the surface of the tumor were bleached white 2 to 5 minutes after application, in sharp contrast to the unaffected mucosa [6].
 

Associations of ABCG4 with chemical compounds

  • The abundant expression of this gene in the brain and close evolutionary relationship to the other members of the subfamily suggests a potential role for ABCG4 in cholesterol transport processes in this tissue [4].
 

Other interactions of ABCG4

  • ABCG4: a novel human white family ABC-transporter expressed in the brain and eye [7].
 

Analytical, diagnostic and therapeutic context of ABCG4

References

  1. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Wang, N., Lan, D., Chen, W., Matsuura, F., Tall, A.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. Yoshikawa, M., Yabuuchi, H., Kuroiwa, A., Ikegami, Y., Sai, Y., Tamai, I., Tsuji, A., Matsuda, Y., Yoshida, H., Ishikawa, T. Gene (2002) [Pubmed]
  3. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. Engel, T., Lorkowski, S., Lueken, A., Rust, S., Schlüter, B., Berger, G., Cullen, P., Assmann, G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Annilo, T., Tammur, J., Hutchinson, A., Rzhetsky, A., Dean, M., Allikmets, R. Cytogenet. Cell Genet. (2001) [Pubmed]
  5. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Cserepes, J., Szentpétery, Z., Seres, L., Ozvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi, B., Elkind, N.B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Diagnosis of early gastric cancers in the upper part of the stomach by the endoscopic Congo red-methylene blue test. Tatsuta, M., Iishi, H., Okuda, S., Taniguchi, H. Endoscopy. (1984) [Pubmed]
  7. ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. Oldfield, S., Lowry, C., Ruddick, J., Lightman, S. Biochim. Biophys. Acta (2002) [Pubmed]
 
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