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Gene Review

SKI  -  SKI proto-oncogene

Homo sapiens

Synonyms: Proto-oncogene c-Ski, SGS, SKV, Ski oncogene
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High impact information on SKI

  • These results indicate that HIPK2, together with c-Ski, plays an important role in the negative regulation of BMP-induced transcriptional activation [1].
  • Furthermore, the c-Ski-induced inhibition of the Smad1/4-dependent transcription was suppressed by a dominant negative form of HIPK2 [1].
  • Thus, Ski and SnoN have the capacity to associate with other proteins, and a complex formation of c-Ski with itself, SnoN, and uncharacterized proteins might play a key role in the function of Ski [2].
  • The c-ski proto-oncogene product (c-Ski) is localized in the nuclei, but its function and biochemical properties are unclear [2].
  • Finally, the calcyclin gene has been localized to the long arm of human chromosome 1, near the ski oncogene [3].

Biological context of SKI


Anatomical context of SKI

  • sno is a member of the ski oncogene family and shares ski 's ability to transform avian fibroblasts and induce muscle differentiation [6].

Regulatory relationships of SKI


  1. Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. Harada, J., Kokura, K., Kanei-Ishii, C., Nomura, T., Khan, M.M., Kim, Y., Ishii, S. J. Biol. Chem. (2003) [Pubmed]
  2. Complex formation between proteins encoded by the ski gene family. Nagase, T., Nomura, N., Ishii, S. J. Biol. Chem. (1993) [Pubmed]
  3. Structural and functional analysis of a growth-regulated gene, the human calcyclin. Ferrari, S., Calabretta, B., deRiel, J.K., Battini, R., Ghezzo, F., Lauret, E., Griffin, C., Emanuel, B.S., Gurrieri, F., Baserga, R. J. Biol. Chem. (1987) [Pubmed]
  4. Structure and activities of the ski oncogene. Colmenares, C., Stavnezer, E. Semin. Cancer Biol. (1990) [Pubmed]
  5. Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation. Ambrose, M.R., Bottazzi, M.E., Goodenow, M.M. DNA Cell Biol. (1995) [Pubmed]
  6. Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Cohen, S.B., Zheng, G., Heyman, H.C., Stavnezer, E. Nucleic Acids Res. (1999) [Pubmed]
  7. Expression and possible mechanism of c-ski, a novel tissue repair-related gene during normal and radiation-impaired wound healing. Liu, X., Zhang, E., Li, P., Liu, J., Zhou, P., Gu, D.Y., Chen, X., Cheng, T., Zhou, Y. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2006) [Pubmed]
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