Disease relevance of Lima1

• Lima bean agglutinin-fluorescein 5-isothiocyanate conjugate (FluNCS-lima bean lectin) interacts with specific receptor molecules on membranes both from the rod outer segment (ROS) of the frog retina and from S49 mouse lymphoma cells [1].
• Bloodmeal sources of Lutzomyia spp. were determined, using the bloodmeal analysis precipitin test, in Chaute, Lima, Peru, an area endemic for cutaneous leishmaniasis (uta) [2].

High impact information on Lima1

• Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton [3].
• Interestingly, the localization of EPLIN to the actin cytoskeleton was maintained in the EWS/Fli-1- or Cdc42-transformed cells, but not in Ras-transformed cells where it was distributed heterogeneously in the cytoplasm [3].
• Epithelial protein lost in neoplasm (EPLIN) is a cytoskeleton-associated protein characterized by the presence of a single centrally located lin-11, isl-1, and mec-3 (LIM) domain [3].
• The analysis of mEPLIN gene revealed that the overall organization of the exons in mouse and human are conserved [4].

Biological context of Lima1

• NIH3T3 cells expressing EPLIN, however, failed to form colonies when transformed by the activated Cdc42 or the chimeric nuclear oncogene EWS/Fli-1 [3].

Anatomical context of Lima1

• Our study indicates EPLIN may function in growth control by associating with and regulating the actin cytoskeleton [3].

Analytical, diagnostic and therapeutic context of Lima1

• A control group was studied in Lima, Peru, 150 m [5].

References