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Gene Review:

TFAP4 - transcription factor AP-4 (activating...

Homo sapiens

Synonyms: AP-4, Activating enhancer-binding protein 4, BHLHC41, Class C basic helix-loop-helix protein 41, Transcription factor AP-4, ...

Cheng, C.K. et al., Badinga, L. et al., Unk, I. et al., Hu, Y.F. et al., Aranburu, A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TFAP4

Transcription factor AP-4 participates in activation of bovine leukemia virus long terminal repeat by p34 Tax [1].

High impact information on TFAP4

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity [2].
EMSAs, UV cross-linking, and Southwestern blot analyses indicated that the basic helix-loop-helix transcription factor AP-4 bound specifically to the two E-box binding sites, whereas an unidentified protein bound to the Ets-like element [3].
Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements [4].
Southwestern blot analysis identified an HepG2 nuclear protein with molecular mass of 48 kDa, similar to that of the bHLH transcription factor AP-4, which bound the CACCTG motif [5].

References

Transcription factor AP-4 participates in activation of bovine leukemia virus long terminal repeat by p34 Tax. Unk, I., Kiss-Toth, E., Boros, I. Nucleic Acids Res. (1994) [Pubmed]
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Hu, Y.F., Lüscher, B., Admon, A., Mermod, N., Tjian, R. Genes Dev. (1990) [Pubmed]
Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene. Cheng, C.K., Hoo, R.L., Chow, B.K., Leung, P.C. Mol. Endocrinol. (2003) [Pubmed]
Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. Aranburu, A., Carlsson, R., Persson, C., Leanderson, T. Biochem. J. (2001) [Pubmed]
A distal regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2) gene interacts with the basic helix-loop-helix transcription factor, AP-4. Badinga, L., Song, S., Simmen, R.C., Simmen, F.A. Endocrine (1998) [Pubmed]

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