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Gene Review:

Asb6 - ankyrin repeat and SOCS box-containing 6

Mus musculus

Synonyms: 2510004M11Rik, AA409356, ASB-6, Ankyrin repeat and SOCS box protein 6

Wilcox, A. et al.

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High impact information on Asb6

In Chinese hamster ovary-insulin receptor (CHO-IR) cells Myc epitope-tagged APS interacted constitutively with FLAG-tagged Asb6 in the presence or absence of insulin stimulation and insulin stimulation did not alter the interaction [1].
We conclude that Asb6 functions to regulate components of the insulin signaling pathway in adipocytes by facilitating degradation by the APS-dependent recruitment of Asb6 and Elongins BC [1].
Immunofluorescence and confocal microscopy studies revealed that Asb6 colocalized with APS in CHO cells and in 3T3-L1 adipocytes [1].
Asb6 was specifically expressed in 3T3-L1 adipocytes as a 50-kDa protein but not in fibroblasts [1].
Asb6 did not appear to undergo tyrosine phosphorylation [1].

Anatomical context of Asb6

In immunoprecipitation studies in CHO cells or 3T3-L1 adipocytes, the Elongin BC complex was found to be bound to Asb6, and activation of the insulin receptor was required to facilitate Asb6 recruitment along with Elongins B/C [1].
However, Asb6 expression appears to be restricted to adipose tissue [1].

References

Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. Wilcox, A., Katsanakis, K.D., Bheda, F., Pillay, T.S. J. Biol. Chem. (2004) [Pubmed]

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